On TV, they were sisters who had an 'us against the world' mentality, constantly banding together to fight evil with their witchy powers. But their real-life connection was far from magic.
An intense feud has been ongoing for more than 20 years now and this week, Milano addressed claims she was the one who got Doherty fired from Charmed.
The actor did so over the weekend during a panel (hosted by Collider) for the TV show, but none of her co-stars accompanied this weekend. They did, however, show up to the same event the day before.
As she spoke to fans, Milano skirted around the feud.
"I knew this was going to come up in one way or another, and I want to be very thoughtful in how I respond to any of this," she said. "I will just say that I'm sad."
She continued, by saying how upset she felt for fans of Charmed, but refused to deny the claims.
"I don't think it's really that I'm sad for me or my life or how it does or does not affect my life," she said.
"I'm the most sad for the fans. I am the most sad that a show that has meant so much to so many people has been tarnished by a toxicity that is still to this day almost a quarter of a century later still happening."
"I'm sad that people can't move past it," added the star. "I'm sad that we all can't just celebrate the success of a show that meant so much to all of us."