The 48 questions Kate McCann has never answered.

Kate and Gerry McCann refused to take part in the new Netflix documentary revisiting the disappearance of their daughter Madeleine in 2007 from a Portuguese holiday villa.

They’ve been fervently trying to find her for the past 12 years, with their persistence in part, making her the most famous missing child in modern history.

But they turned down the opportunity to be interviewed in ‘The Disappearance of Madeline McCann’ releasing a statement on their website which reads;

“We did not see and still do not see how this programme will help the search for Madeleine and particularly given there is an active police investigation, could potentially hinder it.”

The Disappearance of Madeleine McCann trailer. Post continues after video.

Some have argued, that the McCanns would surely welcome any resurgence in interest in their daughter’s case, given she is still missing. But their alleged involvement in her disappearance is something that’s been heavily scrutinised over the years.

A list of questions that Kate McCann refused to answer during police questions has reemerged, published first in The Independent. She used her right to silence in 2007, to stay tight-lipped.

Kate was subjected to 11 hours of gruelling interrogation, after she and her husband were initially named as suspects in the case.

The leading Portuguese detective of the case, Goncalo Amaral, reveals in the documentary he continues to doubt the McCann’s statements.

Amaral and the McCanns are locked in a legal battle over his claims that Maddie died in the family's apartment and that her abduction was faked.

Here are the questions Kate left unanswered:

1. On May 3, 2007, around 22:00, when you entered the apartment, what did you see? What did you do? Where did you look? What did you touch?

2. Did you search inside the master bedroom wardrobe?

3. [Shown two photographs of her bedroom wardrobe] Can you describe its contents?

4. Why was the curtain by the sofa near the side window tampered with? Did someone go behind the sofa?

5. How long did your search of the apartment take after you detected Madeleine’s disappearance?

6. Why did you say Madeleine had been abducted?

7. Assuming Madeleine was abducted, why did you leave the twins to go to the ‘Tapas’ and raise the alarm? The supposed abductor could still be in the apartment.

8. Why didn’t you ask the twins then what happened to their sister or why didn’t you ask them later on?

9. When you raised the alarm at the ‘Tapas’ what exactly did you say – what were your exact words?

10. What happened after you raised the alarm there?

11. Why did you go and warn your friends instead of shouting from the verandah?

12. Who contacted the authorities?

13. Who took place in the searches?

14. Did anyone outside the group learn of her disappearance in those following minutes?

15. Did any neighbour offer you help?

16. What does 'we let her down' mean?

17. Did Jane Tanner tell you that night she’d seen a man with a child?

18. How were the authorities contacted and which police force was alerted?

19. During the searches, with the police there, where did you search for Maddie, how and in what way?

20. Why did the twins not wake up during that search or when they were taken upstairs?

21. Who did you phone after the occurrence?

22. Did you call Sky News?

23. Did you know the danger of calling the media, because it could influence the abductor?

24. Did you ask for a priest?

25. By what means did you divulge Madeleine’s features, by photographs or by any other means?

26. Is it true that during the searches you remained seated on Maddie’s bed without moving?

27 What was your behaviour that night?

28. Did you manage to sleep?

29. Before travelling to Portugal, did you make any comment about a foreboding or a bad feeling?

30. What was Madeleine’s behaviour like?

31. Did Maddie suffer from any illness or take any medication?

32. What was Madeleine’s relationship like with her brother and sister?

33. What was Madeleine’s relationship like with her brother and sister, friends and school mates?

34. As for your professional life, in how many and which hospitals have you worked?

35. What is your medical speciality?

36. Have you ever done shift work in any emergency services or other services?

37. Did you work every day?

38. At a certain point you stopped working. Why?

39. Are the twins difficult to get to sleep? Are they restless and does that cause you uneasiness?

40. Is it true sometimes you despaired at your children’s behaviour and it left you feeling very uneasy?

41. Is it true that in England you even considered handing over Madeleine’s custody to a relative?

42. In England, did you medicate your children? What type of medication?

43. In the case files, you were shown canine forensic testing films. After watching them, did you say you couldn’t explain any more than you already had?

44. When the sniffer dog also marked human blood behind the sofa, did you say you couldn’t explain any more than you already had?

45. When the sniffer dog marked the scent of corpse coming from the vehicle you hired a month after the disappearance, did you say you couldn’t explain any more than you already had?

46. When human blood was marked in the boot of the vehicle, did you say you couldn’t explain any more than you already had?

47. When confronted with the results of Maddie’s DNA, carried out in a British lab, collected from behind the sofa and the boot of the vehicle, did you say you couldn’t explain any more than you already had?

48. Did you have any responsibility or intervention in your daughter’s disappearance?

For more on this topic:

Inside the sex trafficking theory linked to Madeleine McCann's disappearance.

Kate and Gerry McCann have two more children Sean and Amelie.

"This could be the breakthrough": Madeleine McCann Netflix documentary claims she's still alive.

The mysterious case of Rui Pedro, the other missing child in the Madeleine McCann documentary.