The pair, who fell in love on the set of the 2001 action movie The Mexican, were inseparable from the moment they met. She told The Goop Podcast in 2018 that he gave her an "indescribable" feeling.
"[Meeting him] was the first, my life will never be the same [moment] in the most incredible, indescribable way," she confessed. "It's some kind of alchemy. He truly to this day, to this minute, is just my favourite human... We're so lucky in that way, we just really, really like each other."
Watch this clip of Ellen DeGeneres turning Julia Roberts into a Kardashian. Post continues after video.
The couple celebrated their 21st wedding anniversary on July 4 and have worked together on at least half a dozen projects. It's the way they prefer it, with seven weeks being the longest time they've ever spent apart from each other.
While Roberts has had the type of career many actors could only dream of — having won an Academy Award, a BAFTA, and three Golden Globe Awards — she admits the work doesn't "consume" her.