Ita Buttrose is reportedly set to depart Studio 10.

Ita Buttrose is set to depart Studio 10 after four-and-a-half years at the helm of the show.

According to a recent report in TV Tonight, Buttrose will announce the news on Wednesday morning –believed to be her final show — after coming to, what TV Tonight reports, a “mutual decision” with the network.

Buttrose was one the founding cast members of the show.

In a statement confirming the news, Buttrose said she was ready to move on to other projects.

“I’ve had five great years on Studio 10, but it is time for me to move on and focus on other parts of my life, including spending more time with my grandchildren and writing,” she said.

The news comes just months after a bizarre “feud” was reported between castmates Buttrose and Denise Drysdale, after Drysdale threw a bunch of brussel sprouts at her at their Studio 10 Christmas party in December.

“It was something that happened in quick pursuit and sometimes, as we all know, families get out of order and now that it’s almost March 2018 we have left that Christmas behind us and we are looking forward to Christmas 2018,” she said in March of the events of December, telling Fairfax it was a “bowl” full of brussel sprouts that were thrown.

“There is no feud, absolutely not,” she said.

In 2016, in an interview with Mamamia, Buttrose said it was always her dream, after conquering the magazine world, to move into television.

“I had always wanted to host a chat show, and it never came to pass, so you tell yourselves it’s not meant to be. And then out of the blue (TV producer) Adam Boland rang up and approached me,” she told Mia Freedman on No Filter.

Mamamia has reached out to Channel 10 for comment.

Mia Freedman’s interview with Ita Buttrose on No Filter: