Big Brother's Reggie Bird faces another devastating blow following health issues.

She’s gone down in history as one of our favourite Big Brother housemates, but now Reggie Bird could be facing homelessness.

The 43-year-old won the 2003 series of the reality TV show and took home $250,000, but since then Bird has faced a number of challenges.

Bird is legally blind and she’s a single mum to her 10-year-old daughter Mia, and her seven-year-old son Lucas, who has cystic fibrosis.

And now she’s set to be evicted from the home she’s been living in for the past five years.

Bird told Woman’s Day she’s “so scared” about the possibility of homelessness.

Heya @MrSamMac tell little sarah Lucas says hi ????
He has #cysticfibrosis too!#sun7 @sunriseon7 #goodfridayappeal pic.twitter.com/k72nz8kjYm

— REGINA SORENSEN (@BBreggie) April 13, 2017

“One day your kids are cuddled up and warm and safe and just like that, it could all be gone,” she said. “I owe my kids a warm bed and a safe house, that’s not too much to ask, is it?”

The Big Brother alum recently received an eviction notice after an ongoing dispute with her landlord.

“It’s hard to believe I became known as the girl who survived multiple evictions in the Big Brother house, to 14 years later be faced with the real thing,” she said.

“I’ve been having nightmares ever since, wondering where we’re going to go.”

Since leaving the Big Brother house, Bird has been diagnosed with Retinitis Pigmentosa, a degenerative eye condition that’s slowly robbing her of her sight.

After paying $100,000 off her husband’s mortgage, Bird found out that he had cheated on her shortly after she’d left the Big Brother house.

Here is a glimpse me talking about #cysticfibrosis on @Studio10au @strawfie @PEAKS4CF @BenMudgePT @jilli09 @CFAware pic.twitter.com/3rTPFjyiuQ

— REGINA SORENSEN (@BBreggie) March 24, 2017

The pair divorced and Bird’s money problems spiralled from there. She paid $20,000 rent in advance on a rental property in Sydney, but only stayed a few months because the landlord was a “stalker psycho”.

Reggie also lost $40,000 to a “con man” who offered the Big Brother star her own TV show.

The mum-of-two now works part time as telemarketer, while caring for her children, and campaigning for a cure for cystic fibrosis.

Woman’s Day reached out to Bird’s property manager and he said he was “confident” he could find her new accommodation.