Jimmy Kimmel has stepped down from hosting his talk show for a whole week to be with his sick son.

If you tune into Jimmy Kimmel Live! this week, you may notice something missing.

Jimmy Kimmel.

However the TV host’s absence is for a good – and important – reason.

His seven month-old son William John “Billy” Kimmel has undergone “a scheduled and successful heart surgery”, according to a statement released by ABC yesterday.

Young Billy is six months old today. He is healthy and happy and we are all very grateful for your prayers, good wishes, thoughts and support of @ChildrensLA and children’s hospitals in your area.

A post shared by Jimmy Kimmel (@jimmykimmel) on Oct 21, 2017 at 10:17am PDT

It’s the second heart operation Billy has had, the first being at just three days old due to his condition, the tetralogy of Fallot with pulmonary atresia.

“Basically, the pulmonary valve was completely blocked and he has a hole in the wall between the left and right sides of his heart,” the TV host explained in an emotional monologue in May.

“He appeared to be a to be a normal, healthy baby until about three hours after he was born,” he said.

A “very attentive nurse” noticed that Billy had a murmur in his heart and was a “bit purple”.

The second surgery was originally scheduled to take place in October but had to be postponed "due to the common cold".

As a result, Kimmel will "be with his family" this week, including wife Molly McNearney, Billy and three year-old daughter Jane.

Billy is helping me write tonight's monologue. I'll give our thoughts on the #GrahamCassidy health "care" bill. #BillCassidy @LindseyGrahamSC

A post shared by Jimmy Kimmel (@jimmykimmel) on Sep 19, 2017 at 1:39pm PDT

In his place, will be... just about every celebrity you can think of.

Chris Pratt was first off on Monday while the rest of the week features Tracee Ellis Ross, Neil Patrick Harris and Melissa McCarthy as well as guests Margot Robbie, Mary J. Blige, Octavia Spencer, Dave Franco and Hanson.

We're sending love and thoughts to the Kimmels.