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This week, scientists gathered in Washington, DC for the International Summit on Human Gene Editing to discuss a technology called CRISPR-CAS9, which can insert, remove and change the DNA of basically any organism. It is relatively simple, inexpensive and accurate, and it’s already being used in laboratories around the world to make cells and breed laboratory animals with modified DNA for the study of diseases.
CRISPR could also be used to modify DNA in human embryos, but the question is whether this should be allowed.
Among the concerns scientists and bioethicists have highlighted are heritable gene modifications and the use of this technology to create “designer babies.” CRISPR provides new opportunities for disease treatment and prevention, but with unknown and potentially substantial risks that warrant an ethical discussion. And this discussion should be rooted in an understanding of what can and cannot be meaningfully edited.
I study the genetic prediction of complex diseases and traits. Research in my field has consistently shown that human traits and common diseases are not genetic enough to be predicted using DNA tests. For the same reasons, it will be impossible to successfully program the presence of traits in embryos.
Any concerns that CRISPR could taken a step further to enhance babies by selecting favourable traits such as intelligence and athleticism may be unwarranted.
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What can be edited?
The first (and failed) experiment of human embryo editing aimed to repair a single gene mutation for beta-thalassemia, a severe blood disorder. Other diseases mentioned as future targets for gene editing, such as sickle cell disease and Duchenne muscular dystrophy, are caused by single gene mutations.