Meryl Streep completely served Donald Trump in her Golden Globes speech.

After being met with a standing ovation of applause from some of the biggest names in Hollywood, Meryl Streep has used her Golden Globes acceptance speech to condemn US president-elect Donald Trump.

The 67-year-old was awarded the honorary Cecil B Demille award on Sunday evening for her “outstanding contributions to the world of entertainment” and began her speech by explaining she had lost her voice earlier in the week from “screaming in lamentation”.

"I love you all, but you'll have to forgive me," Streep said, "I've lost my voice in screaming in lamentation this weekend."

The Devil Wears Prada actress singled out a number of high-profile actors within the room, listing their birth places and hometowns before explaining Hollywood is "just a bunch of people from other places."

The actress said, "Hollywood is crawling with foreigners and outsiders, and if we kick 'em all out, we'll have nothing to watch but football and mixed martial arts, which are not the arts," Streep said.

The Mamma Mia! star continued, "an actor's only job is to enter the lives of people who are different from us and let you feel what that feels like. And there were many many many powerful performances this year that did exactly that. Breathtaking, compassionate work.

"But there was one performance this year that stunned me; it sank its hooks in my heart. Not because it was good; there was nothing good about it, but it was effective and it did its job. It made its intended audience laugh and show their teeth."

Listen to Mamamia Out Loud discuss why it’s time to stop shouting and start trying to understand the people we don’t agree with. Post continues... 

"It was that moment when the person asking to sit in the most respected seat in the country imitated a disabled reporter; someone he outranked in privilege, power and the capacity to fight back.

"It kind of broke my heart when I saw it, and I still can't get it out of my head because it wasn't in a movie, it was real life," Streep continued.

"And this instinct to humiliate when it's modelled by someone on a public platform, by someone powerful; it filters down into everyone's life because it kind of gives permission for other people to do the same thing. Disrespect invites disrespect. Violence incites violence. When the powerful use their position to bully others, we all lose."

Streep, who once impersonated Trump during the 2016 presidential election, concluded her speech by saying, "As my friend, the dear departed Princess Leia, said to me once, 'Take your broken heart, make it into art.'"

Within moments, social media erupted in applause.

"Yes Meryl Streep, YES!!!! Thank you thank you....a hundred times THANK-YOU!!!," one user wrote.

"MerylStreep said it better than any of us ever could. The greatest actor of all time. Trump voters can mock art. But art always wins," another said.

See more of the Golden Globes highlights here. (Post continues after video.)

"MerylStreep your work, your words.. & your heart is why you are the history lesson our young generation should aspire to be," actor Wilmer Valderrama tweeted.

"Wondrous and much needed speech by Meryl Streep," another said.

Whether or not Trump will respond, only time and Twitter will tell.

Check out all of the red carpet goodness from this 2017 Golden Globes below.