On Friday morning, Victoria woke to the first morning of a fourth COVID-19 lockdown.

The seven-day, statewide shutdown kicked in just before midnight on Thursday, in a bid to contain Melbourne's 26-case City of Whittlesea outbreak.

People are now only able to leave home for five reasons - to shop for food and essential items, provide or receive care, exercise, work or study if they are unable to from home, and to get vaccinated.

To allow more Victorians to get the jab, those aged 40 to 49 are now eligible for the sought-after Pfizer vaccine.

Victorians also now find themselves living under a five-kilometre travel limit for exercise and shopping, and compulsory use of masks both indoors and outdoors.

All non-essential retail is closed but essential stores like supermarkets, bottle shops and pharmacies will remain open, with shopping limited to one person per day, per household.

It's all-too-familiar for Victorians, a return to a way of life they endured for months on end in 2020.

The streets of Melbourne are once again empty, and 'closed' signs are on business doors.

This time there are no JobKeeper payments, putting an extra strain on already struggling businesses.

On Friday morning, Peter Dutton told Today the Federal Government was committed to providing whatever support it could, and would provide Victorian Deputy Premier James Merlino an update about a support package "hopefully today".

But right now, things are eerily familiar and uncertain. On day one of seven, here's how Victorians are reacting.

With every new lockdown announcement, I worry for all those for whom home is one of the most dangerous places they can be. Pandemics do not cause men’s violence against women and children, but they do exacerbate it. #melbournelockdown #COVID19Vic

— Tarang / तरंग (@tarang_chawla)

Fellow Melburnians. It’s ok not to be ok. If you need help, reach-out for it. The #Melbourne #lockdown and re-appearance of masks have acted as a trigger for many who are now experiencing anxiety & PTSD from being through it 3 times before. Look out for each other & be gentle.

— Allan Raskall (@AllanRaskall)

#Melbourne let’s keep our heads up. We are resilient and resourceful. We’ve got through much worse than this and we can do this. Mask up. Stick together. Get vaccinated if you can. Support your local businesses with take away and check on your vulnerable neighbours in need.

— Kon Karapanagiotidis (@Kon__K)

Severe abdominal pain all night. I’m sure it’s a stress response to the Victorian lockdown. How are my fellow Victorians doing? #MorrisonLockdown

— Brittle Sun (@BrittleSun)

#melbournelockdown #day1 🤦‍♀️🥊 pic.twitter.com/QCoTpwWvGQ

— Nicole Bedford (@NicoleBedford19)

Welcome to the sequel ‘a quiet place 4’ #melbournelockdown #CovidVic pic.twitter.com/pROX7zEIHj

— Adam Houghton (@itsjustadamh)

I don't know who needs to hear this but...get outside today. No matter what. It will clear your mind, I promise. #GetOutside #MelbourneLockdown #LYLChallenge

— Amy Pettingill (@amypettingill_)

Angry with the selfishness of people. Angry with the Feds for the botched vax rollout and the HQ debacle. Angry with the State for not acting earlier. Angry with the public health officials for removing the density quotient in offices. We trust these people to protect us. (2)

— Melbourne Iso Girl (@melbourneISO)

Over 40,000 Covid tests in Melbourne yesterday is a stunning response! Gives me hope that we will kick this in the dick once again!! Stay strong, stay healthy & be kind to each other! #melbournelockdown

— Peter Helliar (@pjhelliar)

Sending so much love to everyone in Victoria. pic.twitter.com/i5taISnYvE

— Tracey Spicer AM GAICD (@TraceySpicer)

I was booked to have surgery next Monday, a surgery that was already postponed once because of that 4 month lockdown. Now I have no idea when it’ll happen, so I’m not in the greatest of headspaces, which isn’t helpful for creativity. If you’re in lockdown too, take care (2/2).

— K.M. Allan (@KMAllan_writer)

My husband stood in line for 4 hours in Melbourne today and managed to snag a Pfizer vaccine so we are having a cake to celebrate. #yayScience #melbournelockdown 4.0 pic.twitter.com/jJSslfHtIg

— Carrie Kollias MD FRCSC FRACS (@carrie_kollias)

One thing I like about living in St Kilda is when one bloke in the supermarket has three large packets of toilet paper in his arms another bloke will step up and ask him how many arseholes he has.

— Kent Parkstreet (@thespecialbka)

Got a vaccination booking for Melbourne Showgrounds tomorrow morning! Then promptly burst into tears. One step closer to seeing my family.😭 If you're trying to book on the hotline, just keep calling until you get through. So incredibly grateful to finally be here.

— Jill Stark (@jillastark)

Victorian Hospitals are calmly, methodically gearing their systems up for potential cases, just in case. We know what to do - we have done it before. This time, most #healthcareworkers are vaccinated. The community can have confidence they will be well cared for. #COVID19Vic

— Stephen Parnis (@SParnis)

Asking for a friend. Is it ok to spend the next 7 days in her pjs?

— Chris Sleep (@SleepCmsleep)

So I've had my one outing for the day, is it too early to get back into my PJ's while I work from home today? #victorialockdown #COVID19Vic #WFH #friday

— Lisa 🌻 (@LisasDays)

Just knowing that there are families now telling friends and loved ones that they can’t attend funerals is really triggering for me after going through it myself during last years lockdown. Be kind. You don’t know what people are dealing with on top of the #melbournelockdown

— Melissa Meehan 🐯😷 (@melissameehanau)

AirBNB really needs an option that just reads ‘I’m Victorian’. pic.twitter.com/0bZj6xjpAD

— Joanna McCarthy (@joanna_mcc)

Lockdown sleep in opportunity and I’m wide awake. Big ❤️to all of us in #victorialockdown

— Emily Webb (@emilybwebb)