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Disappearance of Melbourne woman Karen Ristevski "highly irregular", police say.

Police in Melbourne are concerned for the welfare of a 47-year-old woman who has not been seen since Wednesday, calling the behaviour “highly irregular”.

Karen Ristevski of Avondale Heights, in Melbourne’s north-west, was last seen leaving her home on Wednesday morning, wearing a black blazer, jeans and carrying a silver handbag.

She works in retail at the Watergardens Shopping Centre but did not turn up for work at the family business.

Senior Constable Ante Sandric said Ms Risteveski has medical issues, but her family are concerned because her disappearance is out of character.

“Our main concerns are that she hasn’t been seen since leaving her house at about 10:00am on Wednesday,” he said.

“Family haven’t been able to contact her and she hasn’t turned up to work and this is highly irregular.”

Ms Ristevski’s mobile phone is turned off and police said they had very few leads about her disappearance.

Ms Ristevski is described as being Caucasian, about 160cm tall, with a slim build and short brown hair.

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