This post discusses miscarriage and could be triggering for some readers.

Screamco-stars Courtney Cox and David Arquette were once Hollywood's most unlikely couple.

Since meeting at the movie's pre-party, the pair have married, divorced and now co-parent their 17-year-old daughter, Coco.

While both actors prefer to live a life that is relatively private, the pair have had quite the whirlwind marriage and separation that has somehow led them right back to where they began; acting alongside each other inScream 5.

Watch the Scream Official Trailer. Post continues after video.

Cox and Arquette's relationship.

Cox and Arquette first met at a pre-party before filming began for the slasher thriller filmScreamin 1996 - and while 50-year-old Arquette knew it was 'love at first sight' for him, the same couldn't be said for Cox, who played level-headed reporter 'Gale Weathers'.

"For me it was, but not for her. I had to trick her," he revealed toBang Media, via Digital Spy, in 2009. "We met at a pre-party before we started filmingScream. I was being a little cocky and Courteney was like, ‘Ah, I’ve heard of you,’ and we just kept flirting for a while. She’s just so gorgeous and she jokes around so much."

Cox, 57, admitted she initially was terrified by her on-screen co-star who played the dopey 'Deputy Dewey Riley'.

"I was intimidated by David," she explained. "He has lived many, many lives I think. He is a worldly boy. He has done more things in his young years than I have in my whole life. So he taught me a lot."

By 1998, Arquette had proposed to Cox and in 1999, the pair were married in a reportedly extravagant ceremony in San Francisco.

In attendance was all of Cox'sFriendsco-stars, including Jennifer Aniston's ex-husband Brad Pitt and Patricia Arquette's former husband Nicolas Cage.

Following their marriage, the pair were open about their attempts to have children together, with Cox admitting she'd sadly miscarried "quite a few times" due to a genetic mutation which resulted in her own antibodies attacking the fetus within her body.

Speaking toNBCin 2004, she revealed the difficulties in having to play a comedic character, while dealing with her own personal struggles.

"I remember one time I just had a miscarriage and Rachel (played by Jennifer Aniston) was giving birth. It was like that same time," she explained.

"Oh my God, it was terrible having to be funny."

After two rounds of IVF, Cox and Arquette went on to welcome their daughter in 2004, Coco, who is now 17-years-old.

Cox said: "I had a lot of miscarriages and I don't think that's something people shouldn't talk about because it's… unfortunate, but it happens.

"I just think it's important to get things out there so people can realise they're not alone."

On becoming a father, Arquette said in 2019: "To me, once you have that kid, it sort of redefines your understanding of love. And it just sort of like I don't know, it gives you a new perspective on life..."

Separation and divorce.

A few years into the pair's marriage, cracks began to show, but they were determined to try to work it out.

"We've done couples therapy in the past. We're not lazy about our marriage. We have the same arguments we've had for years," Cox and Arquette said in a joint statement, back in 2011.

"We have agreed to a trial separation that dates back for some time. The reason for this separation is to better understand ourselves and the qualities we need in a partner and for our marriage. We remain best friends and responsible parents to our daughter and we still love each other deeply."

In 2012, it was reported Cox officially filed for divorce from Arquette, confessing toHoward Sternshe and her partner were "completely the opposite".

"There are a lot of things that David likes to do completely the opposite things I do," she said. "I don't want to inhibit him in his life. He really is a very gregarious guy, he's very outgoing. I'm much more of an introvert."

On his part, Arquette told Howard Stern in 2011 during a joint interview, that Cox had grown tired of his antics and didn't want to "mother" him any longer.

Cox went on to explain her ex-husband's insatiable sex drive also drove a wedge between them.

While on a trip to Disney World with their then-six-year-old, she said he'd tried to make a move on her.

"It was early in the morning. This is one of our problems in our relationship. Whenever I would need consoling from David, he could not literally put his arm around me for one second without completely getting a boner," she said. "So [Disney World] just wasn't the right time and I don't want to confuse the issue. We're going through a hard time."

The pair finalised their divorce in 2013, after 14 years of marriage.

Other relationships.

Since then, both actors have gone on to date other people, with Arquette finding love again with 33-year-old entertainment host Courtney McLarty who he met at a Camp Playboy event at Comic-Con.

They share two children together, seven-year-old Charlie West and four-year-old Augustus Alexis.

In 2015, he and McLarty married.