Breakthrough in case of missing toddler Baden Bond as two people charged with murder.

Police have made a breakthrough in the cold case of missing toddler Baden Bond, arresting his parents on Thursday more than a decade after his disappearance.

Baden Bond was just 22-months-old when he was last seen at his home in Woodridge, south of Brisbane, on March 27, 2007.

He was not reported missing until nine years later. There are no records of him attending any school or medical appointment from 2007 onwards.

Now, the toddler’s parents — 43-year-old Dina and 49-year-old Shane — have been taken into custody and charged with murder.

On Friday morning they appeared briefly in the Brisbane Magistrates Court, but the case was adjourned until April 10, according to AAP.

Outside the court, Detective Inspector Damien Hansen said investigation would now focus on finding the Baden's remains.

"It's unimaginable that somebody could do that to a 22-month-old child," he told reporters.

It is alleged the toddler was killed sometime between March 26 and May 17, 2007, at Woodridge or elsewhere in the state of Queensland.

The arrests came just two days after police launched a public appeal for information on the toddler, adding that they believed Baden -- who would now be 12-years-old -- had likely been murdered.

BREAKING: Two in custody in relation to missing toddler Baden Bond.
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— 7News Yahoo7 (@Y7News) March 16, 2017

On Wednesday, Hansen said police had been unable to "find any evidence of Baden existing" after the date he was last seen.

"We do know that he was alive on that date. Someone out there must know what happened to a two-year-old child," he told the media.

Baden's family moved from their Woodridge home to New South Wales less than six months after he disappeared, and had given police a "number of versions" of where Baden was.

It is believed the family told officers their son was in the care of the Department of Child Safety, but Detective Inspector Damien Hansen said police had searched "every possible location for Baden".

"[The family has] given us versions that he is with relatives, he is with other people. Certainly all our investigations have proved negative," he said on Wednesday.

Queensland Police began digging up the backyard of a Wagawn St property in Woodridge last year, where they found bones.

The bones are still being forensically examined to determine whether they are human, and police say the results could still be a few months away.

LISTEN: What it's like when a loved one goes missing. Loren O'Keeffe shares her story on No Filter.