Ana Maria Henao had come to Madrid for a fresh start. At 40, family say, she was mid-divorce and ready to breathe somewhere new.

She never had the chance.

On a February afternoon, she arrived home to her apartment building.

Surveillance footage captured her walking in as though it was any other day.

By the next day, she was gone.

That evening, she called her friend Sanna Rameau, who told People that she acted "totally normal".

Around 10pm, Ana sent her last text message to her friends.

What Ana didn't know was that at 9:30pm, a man in a motorcycle helmet was seen entering her building. Surveillance footage captured him spray-painting the lobby's security camera.

Later, he appeared to leave carrying what authorities believed to be a rolling suitcase.

The next day, Sanna received another text from her friend. But this time, something didn't seem right.

According to the text, Ana had met a man and was going to his home, where service would be spotty. According to Sanna, it seemed flat and emotionless, unlike Ana.

Another friend received a similar message in Spanish, according to the Associated Press (AP). This one looked as if it had been run through Google Translate.

Sanna was concerned.

"She wouldn't do this… it is very unsafe and crazy behaviour," Sanna said, per the AP.

When Ana stopped replying, Sanna called the police.

That was more than two years ago. Ana hasn't been seen since.

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Ana is a naturalised American, originally from Colombia, who had been living in South Florida.

Family and friends told AP that she had moved to Spain for some space amid a contentious divorce from her Serbian husband David Knezevich.

The couple had been married for 13 years, building a real estate portfolio worth more than $8 million across 15 different properties, according to Tampa Bay Times.

According to The Times, Knezevich began selling the properties in October 2023 and kept the profits.

In a civil complaint filed in May 2026, Ana's brother, Felipe, claimed that Knezevich and his lawyers had systematically drained his sister of about $6 million in equity through fraudulent transactions for over a year.

On the morning that she disappeared, Ana reportedly signed a deal for the sale of a $900,000 home in Oakland Park, Florida, but her brother claimed her family never saw a cent.

She had only been in Madrid for five weeks when she went missing in February 2024, per AP.

Ana Maria moved to Spain five weeks before she went missing. Image: FBI.

Following her disappearance, Spain's Missing Persons Association posted Ana's photo throughout Madrid.

Their investigations led the FBI to that helmeted man who entered Ana's building on February 2, 2024, before leaving with a suitcase.

FBI believe that man was Knezevich. Inside that suitcase, they believe, was Ana's body.

Prosecutors said they had strong evidence to prove it. They believe he flew from Miami to Turkey six days before Ana went missing. From there, he allegedly travelled to Serbia, where he rented a car and drove to Madrid.

He was allegedly captured on surveillance footage in a Madrid hardware store buying duct tape and spray paint — the same brand the man in the motorcycle helmet used.

When Knezevich returned the rental car, prosecutors said it had been driven over 7,000 kilometres, its windows had been tinted, two identifying stickers had been removed and there was evidence that the license plate had been removed and put back on, according to AP.

Three months after those strange text messages, Knezevich was arrested and charged with one count of kidnapping in connection with his wife's disappearance.

After pleading not guilty to the kidnapping charge, Knezevich was charged again. This time, with kidnapping resulting in death, foreign domestic violence resulting in death and foreign murder of a US national, per AP. He was jailed without bond.

Knezevich was awaiting trial at the Federal Detention Center in Miami when he was found unresponsive on April 28, 2025, according to a statement from the Federal Bureau of Prisons. He died by an apparent suicide, his attorney later confirmed to US outlets, including CNN.

Ana's family released a statement sharing that his death closed "a painful chapter" in their lives.

But his death left questions unanswered.

"Now, we may never know where he put Ana's body," the statement read.

"It is a cruel final insult that we may never recover Ana's remains or know the full extent of the betrayal she suffered.

"Still, we remain committed to seeking the truth and justice for Ana through our attorney, Mr Ingber, and to preserving Ana's memory while honouring her life with dignity, strength and love."

It's been more than two years since Ana went missing and more than a year since Knezevich died. Her body hasn't been found.

The FBI's Miami Field Office has said that evidence known to date indicates that she is dead.

Investigators believe Knezevich disposed of Ana's body during his drive back to Serbia.

The FBI is offering a reward of up to $25,000 USD for information leading to the location of Ana's body.

Speaking to Tampa Bay Times last month, Felipe shared the impact their loss has had on their family.

"My mum doesn't have a daughter anymore. I don't have a sister anymore. My son was never able to meet his aunt, his only aunt on my side of the family," Felipe said.

"At some point, it's just got to stop being about lawsuits and real estate and just be that a life was lost, and the people who were involved in all of this need to be held accountable."

Feature image: The National Centre for Missing Persons in Spain/FBI.