We would have loved another but alas it's not in the cards for us.  So we one and done but not our choice.    

When I was younger I was told that my vomiting every month was in no way related to my periods.  How many others have been told the same thing about this symptom and the others listed? Lucky with time and by the time I finished uni it has passed.  Everyday life at that time was tough knowing that every month I would be out of action for at least 3 days of the month. 

Happens with siblings as well.  They decided when the left the family home not only do they not have a mother but also a sister and nephew.  Anyways it's their loss not ours.  I don't waste time thinking or hoping for a reconnection or what they are doing.  Life's too short.