$900 million worth of crystal meth hidden between floorboards has been seized by police.

The seizure of a record amount of the drug ice by Australian police has dealt a serious blow to organised crime, Justice Minister Michael Keenan says.

The 903kg haul valued at almost $900 million was on its way to Melbourne when it was intercepted by a joint operation involving Australian Federal Police and Victoria Police.

“This successful result cannot be under-estimated. It is a very serious blow to organised crime around the country,” Mr Keenan told reporters on Wednesday.

AFP images show the massive amount of crystal methamphetamine, equivalent to nine million individual hits, was hidden between floorboards.

AFP Assistant Commissioner Neil Gaughan said the drugs were discovered at a property in Nunawading in Melbourne’s east after the arrest of two Victorian men in February.

“We located 70 boxes of floorboards similar to what you see in front of you here today,” he said.

"In each of those floorboards was concealed between the floorboards 2kg of methamphetamine."

A 53-year-old Blackburn man and a 36-year-old Doncaster man have been charged with trafficking in a commercial quantity of illegal narcotics.

Victoria Police Assistant Commissioner Stephen Fontana said the record haul of ice was discovered following an investigation into a drug syndicate, which resulted in the seizure of 40kg of methamphetamine, 175,000 cigarettes and also $140,000 in cash and other contraband.

He said the investigation was ongoing and police were searching for two Asian men who may have links to the syndicate and are believed to frequent the Box Hill area in Melbourne.